Roles of common environmental endocrine disrupters in development and progress of breast cancer:a review of recent studies
【Abstract】 Endocrine disrupters(EDs) are widely found in food-packaging materials,cosmetics,etc. and environmental media.This paper summarized the studies of several synthetic xenoestrogens(bisphenolA,phthalates,polychlorinated biphenyls) and their roles in breast cancer tumorigenesis,including the distribution in the environment and in the human body,and the routes and levels of exposure. Epidemiological studies examining the relationship between exposure of EDs and breast cancer were also included. Furthermore,the studies on the mechanisms of action of BPA were also summarized,such as genetic and epigenetic regulation,ER-mediated xenoestrogenic activity,induction of ROS,activation of ER-independent signaling pathways,and regulation via micro-environment.Understanding the effects and mechanisms of EDs involved in breast cancer development would help to reduce EDs exposure and provide further information for future research.
【Key words】 Endocrine disruptors； Breast cancer； Bisphenol A； Phthalates； Polychlorinated biphenyls；
- 【文献出处】 环境与健康杂志 ,Journal of Environment and Health , 编辑部邮箱 ,2018年10期