Level of interleukin-1β and its relationship with symptoms in stable patients with schizophrenia
【Abstract】 Objective:To explore the level of plasma interleukin-1β(IL-1β) in stable schizophrenic patients, and its relationship with clinical symptoms. Method:75 patients with stable schizophrenia(patient group) and 40 healthy controls(control group) were enrolled.The levels of plasma IL-1β were detected by flow multiplex protein analysis.The clinical symptoms of patients were assessed by Positive and Negative Symptom Scale(PANSS). Results:The level of plasma interleukin-1β [(2.10±0.59) pg/mL] in the patient group was higher than that in the control group [(1.90±0.28) pg/mL](P<0.05).There were no significant differences in plasma IL-1β levels of patients with different gender, smoking or family history of mental illness(all P>0.05).The level of plasma IL-1β in the patient group had no correlation with gender, age, education years, age of first onset, age of first hospitalization, total course of illness, drug dose(all P>0.05).The level of IL-1β was negatively correlated with reaction deficiency factor(r=-0.24,P=0.05),paranoid factor(r=-0.36,P=0.00),activator factor(r=-0.29,P=0.02). Conclusion:The patients with stable schizophrenia have higher plasma level of IL-1β than healthy controls, which exists a certain relationship with the severity of clinical symptoms.
- 【文献出处】 临床精神医学杂志 ,Journal of Clinical Psychiatry , 编辑部邮箱 ,2021年03期