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稳定期精神分裂症患者血浆白介素-1β水平及其与症状关系

Level of interleukin-1β and its relationship with symptoms in stable patients with schizophrenia

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【作者】 冯薇贾强谭淑平李佳王志仁黄隽超谭云龙

【Author】 FENG Wei;JIA Qiang;TAN Shu-ping;LI Jia;WANG Zhi-ren;HUANG Jun-chao;TAN Yun-long;Beijing Huilongguan Hospital;

【通讯作者】 谭云龙;

【机构】 北京大学回龙观临床医学院北京回龙观医院

【摘要】 目的:探讨稳定期精神分裂症患者血浆白介素-1β(IL-1β)水平及其与临床症状的关系。方法:纳入稳定期精神分裂症患者75例(患者组)和健康对照者40名(对照组),采用流式多重蛋白分析技术检测血浆炎症因子IL-1β的浓度,采用阳性与阴性症状量表(PANSS)评定患者临床症状。结果:患者组IL-1β水平[(2.10±0.59)pg/ml]较对照组[(1.90±0.28)pg/ml]高(P<0.05);不同性别、是否吸烟、是否有精神疾病家族史患者之间血浆IL-1β水平差异无统计学意义(P均>0.05);患者组血浆IL-1β水平与性别、年龄、受教育年限、首次发病年龄、首次住院年龄、总病程、用药剂量(折合氯丙嗪等效剂量)无相关(P均>0.05)。患者组血浆IL-1β水平与PANSS中反应缺乏因子(r=-0.24,P=0.05)、偏执性因子(r=-0.36,P=0.00)、激活因子(r=-0.29,P=0.02)呈负相关。结论:稳定期精神分裂症患者血浆IL-1β浓度高于健康对照者,其与临床症状严重程度存在一定联系。

【Abstract】 Objective:To explore the level of plasma interleukin-1β(IL-1β) in stable schizophrenic patients, and its relationship with clinical symptoms. Method:75 patients with stable schizophrenia(patient group) and 40 healthy controls(control group) were enrolled.The levels of plasma IL-1β were detected by flow multiplex protein analysis.The clinical symptoms of patients were assessed by Positive and Negative Symptom Scale(PANSS). Results:The level of plasma interleukin-1β [(2.10±0.59) pg/mL] in the patient group was higher than that in the control group [(1.90±0.28) pg/mL](P<0.05).There were no significant differences in plasma IL-1β levels of patients with different gender, smoking or family history of mental illness(all P>0.05).The level of plasma IL-1β in the patient group had no correlation with gender, age, education years, age of first onset, age of first hospitalization, total course of illness, drug dose(all P>0.05).The level of IL-1β was negatively correlated with reaction deficiency factor(r=-0.24,P=0.05),paranoid factor(r=-0.36,P=0.00),activator factor(r=-0.29,P=0.02). Conclusion:The patients with stable schizophrenia have higher plasma level of IL-1β than healthy controls, which exists a certain relationship with the severity of clinical symptoms.

【关键词】 精神分裂症临床症状白介素-1β
【Key words】 schizophreniaclinical symptomsinterleukin-1β
【基金】 北京市医管局临床技术创新项目(XMLX201513);国家自然科学基金国际(地区)合作项目(中芬)(81461130016)
  • 【文献出处】 临床精神医学杂志 ,Journal of Clinical Psychiatry , 编辑部邮箱 ,2021年03期
  • 【分类号】R749.3
  • 【下载频次】83
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