Comparative study on efficacy of topiramate and metformin in the treatment of obesity induced by antipsychotics
【Abstract】 Objective: To explore the efficacy and safety of topiramate and metformin in the treatment of obesity induced by antipsychotics. Method:62 schizophrenic patients with obesity and stable condition caused by antipsychotics were randomly divided into topiramate group and metformin group.On the basis of the type and dose of the original antipsychotics, the corresponding topiramate and metformin were given.Positive and Negative Symptom Scale(PANSS) was used to evaluate, and body weight, body mass index(BMI) and waist hip ratio(WHR) were measured before and after intervention; meanwhile, the safety was evaluated. Results:(1)Compared with baseline, there were significant differences in body mass, BMI and WHR at 4,8 and 12 weeks, the total score of PANSS and general pathological score at 12 weeks in the topiramate group(all P<0.01),while in the metformin group there were significant differences in WHR at 4,8 and 12 weeks, body mass and BMI at 8 and 12 weeks, the total score of PANSS at 12 weeks compared with baseline(P<0.05 or P<0.01).(2)The change rate of body mass at each time point, the WHR at 4 and 8 weeks after intervention in the topiramate group were significantly higher than those in the metformin group(P<0.05 or P<0.01).The total score of PANSS,negative symptom score and general pathological score in the topiramate group were significantly lower than those in the metformin group(all P<0.01).The proportion of body mass decrease >7% was not significantly different between the two groups.(3)After 38 weeks of intervention, there were significant differences in body weight and BMI between the two groups compared with baseline(all P<0.05). Conclusion:Topiramate and metformin have significant short-term and long-term effects on reducing body weight of patients with obesity induced by antipsychotics, with good safety, and topiramate has better effect on improving negative symptoms of patients.
- 【文献出处】 临床精神医学杂志 ,Journal of Clinical Psychiatry , 编辑部邮箱 ,2021年03期