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帕利哌酮缓释片与利培酮改善老年精神分裂症患者社会功能的对照研究

Comparative study of paliperidone extended-release and risperidone in improving social function of elderly patients with schizophrenia

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【作者】 蔡清艳段明君简薇阮熙罗微彭静

【Author】 CAI Qing-yan;DUAN Ming-jun;JIAN Wei;RUAN Xi;LUO Wei;PENG Jing;Department of Geriatric Psychiatry,the Fourth People’s Hospital of Chengdu;

【通讯作者】 蔡清艳;

【机构】 成都市第四人民医院老年精神科

【摘要】 目的:探讨帕利哌酮缓释片对老年期精神分裂症患者社会功能的改善。方法:107例老年期精神分裂症患者被随机分为帕利哌酮组54例和利培酮组53例,分别于基线及180 d时采用个人和社会功能量表(PSP)从社会中有用的活动、个人和社会的关系、自我照料、干扰和攻击行为4个维度进行社会功能评估;随访结束时进行药物满意度问卷(MSQ量表)调查。结果:两组在治疗终点时PSP评分与基线相比均有显著提高(P<0.01),帕利哌酮组比利培酮组社会功能改善更明显,差异具有统计学意义(P<0.01)。治疗后,帕利哌酮组药物满意率为70.4%,明显高于利培酮组(39.6%)(χ~2=10.22,P=0.001)。结论:帕利哌酮缓释片能够明显改善老年精神分裂症患者的社会功能,提高患者的生活质量和药物治疗满意度。

【Abstract】 Objective: To investigate the improvement of social function of paliperidone extended-release(ER) in elderly patients with schizophrenia. Method:107 senile patients with schizophrenia were randomly divided into the paliperidone group(n=54) and the risperidone group(n=53).The social function was assessed with the Personal and Social Performance Scale(PSP) at baseline and 180 days after follow, which includes four dimensions such as useful activities in society, relationship between individuals and society, self-care, interference and aggressive behavior.The medication satisfaction questionnaire(MSQ) was conducted at the end of follow-up. Results:At the end of treatment, the PSP scores of the two groups significantly increased compared to the baseline(P<0.01).The improvement of social function in the paliperidone group was more significant than that in the risperidone group, with significantly statistical difference(P<0.01).After treatment, the satisfaction rate in the paliperidone group(70.4%) was higher than that in the risperidone group(39.6%)(χ~2=10.22,P=0.001). Conclusion:Palipiperidone ER can significantly improve the social function, the quality of life and the treatment satisfaction of elderly patients with schizophrenia.

  • 【文献出处】 临床精神医学杂志 ,Journal of Clinical Psychiatry , 编辑部邮箱 ,2021年03期
  • 【分类号】R749.3
  • 【下载频次】47
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