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基于9种RNA的肾透明细胞癌预后模型建立与验证

Identification of nine RNAs signature and risk score for prognosis of clear cell renal cell carcinoma

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【作者】 管波单卫民

【Author】 GUAN Bo;SHAN Weiming;Department of Urology,Fuyang People’s Hospital;

【通讯作者】 管波;

【机构】 安徽省阜阳市人民医院泌尿外科

【摘要】 目的构建肾透明细胞癌预后分子标签及列线图。方法提取癌症基因组图谱(TCGA)数据库中相关数据,利用R语言及其相关算法包对数据进行差异表达分析、Lasso-Cox回归分析构建肾透明细胞癌预后分子标签,并联合临床数据构建肾透明细胞癌预后列线图。结果筛选出530例肾透明细胞癌患者肿瘤及正常肾组织中差异表达的RNA 5 759种,进一步采用Lasso-Cox回归分析从中筛选出9种肾透明细胞癌预后相关RNA,分别为DYNLL1P4、LINC01956、PLG、SNORA70B、ZIC2、AC011700.1、AC091812.1、AC104958.1、AL133255.1,并构建了肾透明细胞癌预后分子标签:0.255 5×EXPDYNLL1P4+0.144 2×EXPLINC01956-0.069 5×EXPPLG+0.253 4×EXPSNORA70B+0.084 2×EXPZIC2+0.234 2×EXPAC011700.1+0.103 6×EXPAC091812.1+0.257 5×EXPAC104958.1+0.132 6×EXPAL133255.1。结论通过对TCGA数据库的挖掘,发现对肾透明细胞癌预后有影响的9种基因,且联合9种RNA构建的分子标签与肾透明细胞癌患者的预后有显著性关联,构建的肾透明细胞癌预后模型有望应用于临床。

【Abstract】 Objective To construct the prognostic molecular label and nomogram of renal clear cell carcinoma. Methods The relevant data were extracted from TCGA database,and R language and its related algorithm package were used to construct the prognostic molecular label of renal clear cell carcinoma by analysis of the differential expression of the data and Lasso-Cox regression analysis.The prognostic nomogram of renal clear cell carcinoma was constructed based on clinical data. Results There were 5 759 differentially expressed RNAs between normal renal tissues and tumor tissues.Nine kinds of RNAs related to the prognosis of renal clear cell carcinoma were screened by Lasso-Cox regression analysis.They were DYNLL1 P4,LINC01956,PLG,SNORA70 B,ZIC2,AC011700.1,AC091812.1,AC104958.1,AL133255.1.The molecular label of prognosis of renal clear cell carcinoma was constructed:0.255 5×EXPDYNLL1 P4+0.144 2×EXPLINC01956-0.069 5×EXPPLG+0.253 4× EXPSNORA70 B +0.084 2× EXPZIC2 +0.234 2× EXPAC011700.1 +0.103 6×EXPAC091812.1+0.257 5×EXPAC104958.1+0.132 6×EXPAL133255.1. Conclusions We found 9 genes that affected the prognosis of renal clear cell carcinoma,and constructed molecular label could predict the prognosis of patients with renal clear cell carcinoma.There was a significant correlation between the molecular label and the prognosis of patients with renal clear cell carcinoma.The prognosis model of renal clear cell carcinoma may be used in clinic in the future.

【关键词】 肾透明细胞癌预后模型
【Key words】 Clear cell renal cell carcinomaPrognosisModel
【基金】 2019年度安徽省阜阳市卫生健康委科研立项课题(FY2019-031)
  • 【文献出处】 现代泌尿生殖肿瘤杂志 ,Journal of Contemporary Urologic and Reproductive Oncology , 编辑部邮箱 ,2021年03期
  • 【分类号】R737.11
  • 【下载频次】80
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